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Mufti, S. T., Falemban, A., & Rizwan, Z. (2018). Clinicopathological Features of Melanocytic Nevi and Their Correlation to Cutaneous Melanoma among Patients Attending King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Sudan Journal of Medical Sciences (SJMS), 13(2), 98-113. https://doi.org/10.18502/sjms.v13i2.2641
https://doi.org/10.18502/sjms.v13i2.2641
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S. T. Mufti
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A. Falemban
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Z. Rizwan
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Published Date
- Jun 28, 2018
Clinicopathological Features of Melanocytic Nevi and Their Correlation to Cutaneous Melanoma among Patients Attending King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Abstract
Melanocytic nevi (MN) pose diagnostic difficulty due to their heterogeneous clinical, biological and molecular characteristics. Their recognition is also important because cutaneous melanomas are known to arise in pre-existing MN. Aim: This retrospective study aims to examine the clinical features and histopathological types of MN among patients attending King Abdulaziz University Hospital between January 2000 and December 2017. It also aims to examine the correlation of their number to cutaneous melanoma. Materials and Methods: All biopsy specimen data of pigmented skin lesions were collected through an electronic search of the Anatomic Pathology archives. Age, gender and site distribution and histological features were studied
for different MN and their relation to cutaneous melanoma if associated. Results: MN were most common in the third decade of life affecting females more than males. The most frequent anatomic location was the head region, 176 (45.3%), with face being most frequent site, 45 (25.5%). Histologically the most common MN was
intradermal type accounting for 217 (56%). Two dysplastic nevi and one congenital nevus was associated with cutaneous melanoma. Conclusion: MN most commonly affected patients in their third decade of life .Females were more affected than males. Histologically most MN were of intradermal type and were rarely associated with cutaneous melanoma.
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[32] Al Hawsawi, K., Al Zahrani, B., Bamani, S., et al. (2016). Acquired melanocytic nevus:
An unusual case presentation. The Open Dermatology Journal, vol. 1, no. 1, pp. 6-8.
[2] Barnhill, R. L., Cerroni, L., Cook, M., et al. (2010). State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: Outcome of an international workshop. Advances in Anatomic Pathology, vol. 17, no. 2, pp. 73-90.
[3] Lin, W. M., Luo, S., Muzikansky, A., et al. (2015). Outcome of patients with de novo versus nevus-associated melanoma. Journal of the American Academy of Dermatology, vol. 72, no. 1, pp. 54-58.
[4] Valiukeviciene, S., Gollnick, H., Stang, A. (2007). Body-site distribution of common acquired melanocytic nevi associated with severe sunburns among children in Lithuania. International Journal of Dermatology, vol. 46, no. 12, pp. 1242-1249.
[5] Al Hawsawi, K., Al Zahrani, B., Bamani, S., et al. (2016). Acquired melanocytic nevus: An unusual case presentation. The Open Dermatology Journal, vol. 1, no. 1, pp. 6-8.
[6] Lopez-Ravello, B. M., Arias-Santiago, S., Fernandez-Pugnaire, M. A., et al. (2015). Prevalence of common and atypical melanocytic nevi in young adults and its relationship with sun protection and exposure habits. European Journal of Dermatology, vol. 25, no. 1, pp. 45-51Z.
[7] Haenssle, H. A., Mograby, N., Ngassa, A., et al. (2016). Association of patient risk factors and frequency of nevus-associated cutaneous melanomas. JAMA Dermatology, vol. 152, no. 3, pp. 291-298.
[8] Haenssle, H. A., Mograby, N., Ngassa, A., et al. (2016). Association of patient risk factors and frequency of nevus-associated cutaneous melanomas. JAMA Dermatology, vol. 152, no. 3, pp. 291-298.
[9] Huang, J. M., Chikeka, I., and Hornyak, T. J. (2017). Melanocytic nevi and the genetic and epigenetic control of oncogene-induced senescence. Dermatologic Clinics, vol. 35, no. 1, pp. 85-93.
[10] Mufti, S. T. (2012). Pattern of cutaneous melanoma at King Abdul Aziz University Hospital, Jeddah, Saudi Arabia. Pakistan Journal of Medical Sciences, vol. 28, no. 1, pp. 154-157.
[11] Al-Dawsari, N. A. and Amra, N. (2016). Pattern of skin cancer among Saudi patients attending a tertiary care center in Dhahran, Eastern Province of Saudi Arabia: A 20- year retrospective study. International Journal of Dermatology, vol. 55, no. 12, pp. 1396-1401.
[12] Al-Shahrani, Z. S., Al-Rawaji, A. I., Al-Madouj, A. N., et al. (Sep 2017). Cancer Incidence Report Saudi Arabia 2014. Ministry of Health, Kingdom of Saudi Arabia. Retrieved from http://www.chs.gov.sa/Ar/HealthCenters/NCC/ CancerRegistry/CancerRegistryReports/2014.pdf (accessed March 21, 2018).
[13] Alexandrescu, D. T., Maslin, B., Kauffman, C. L., et al. (September 2013). Malignant melanoma in pigmented skin: Does the current interventional model fit a different clinical, histologic, and molecular entity? Dermatologic Surgery, vol. 39, no. 9, pp. 1291-1303.
[14] Weatherhead, S. C., Haniffa, M., and Lawrence, C. M. (2007). Melanomas arising from nevi and de novo melanomas-Does origin matter? British Journal of Dermatology, vol. 156, no. 1, pp. 72-76.
[15] Longo, C., Rito, C., Beretti, F., et al. (2011). De novo melanoma and melanoma arising from pre-existing nevus: In vivo morphologic differences as evaluated by confocal microscopy. Journal of the American Academy of Dermatology, vol. 65, no. 3, pp. 604-614.
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29450912].
[17] Patton, E. E., Widlund, H. R., Kutok, J. L., et al. (2005). BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Current Biology, vol. 15, no. 3, pp. 249-254.
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[19] Scurr, L. L., McKenzie, H. A., Becker, T. M., et al. (2011). Selective loss of wild-type p16(INK4a) expression in human nevi. Journal of Investigative Dermatology, vol. 131, no. 11, pp. 2329-2332.
[20] Karram, S., Novy, M., Saroufim, M., et al. (2013). Predictors of BRAF mutation in melanocytic nevi: Analysis across regions with different UV radiation exposure. The American Journal of Dermatopathology, vol. 35, no. 4, pp. 412-418.
[21] Roh, M. R., Eliades, P., Gupta, S., et al. (2015). Genetics of melanocytic nevi. Pigment Cell & Melanoma Research, vol. 28, no. 6, pp. 661-672.
[22] Budair, F., Aljabre, S., Alquorain, N., et al. (2017). Journal of Dermatology & Dermatologic Surgery, vol. 21, no. 2, pp. 53-57.
[23] Duffy, K. and Grossman, D. (2012). The dysplastic nevus: From historical perspective to management in the modern era: Part II. Molecular aspects and clinical management. Journal of the American Academy of Dermatology, vol. 67, no. 1, p. 19, e1-12; Quiz 31-32.
[24] Kinsler, V. A., O’Hare, P., Bulstrode, N., et al. (2017). Melanoma in congenital melanocytic naevi. British Journal of Dermatology, vol. 176, no. 5, pp. 1131-1143.
[25] Simons, E. A., Huang, J. T., and Schmidt, B. (2017). Congenital melanocytic nevi in young children: Histopathologic features and clinical outcomes. Journal of the American Academy of Dermatology, vol. 76, no. 5, pp. 941-947.
[26] Krengel, S. and Reyes-Múgica, M. (2017). Melanoma risk in congenital melanocytic naevi. British Journal of Dermatology, vol. 176, no. 5, p. 1114.
[27] Dika, E., Ravaioli, G. M., Fanti, P. A., et al. (2017). Spitz tumors spitz nevi and other spitzoid neoplasms in children: Overview of incidence data and diagnostic criteria. Pediatric Dermatology, vol. 34, no. 1, pp. 25-32.
[28] Tetzlaff, M. T., Reuben, A., Billings, S. D., et al. (2017). Toward a Molecular-Genetic Classification of Spitzoid Neoplasms, Clinics in Laboratory Medicine, vol. 37, no. 3, pp. 431-448.
[29] Van Raamsdonk, C. D., Bezrookove, V., Green, G., et al. (2009). Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature, vol. 457, no. 7229, pp. 599-602.
[30] Damsky, W. E. and Bosenberg, M. (2017). Melanocytic nevi and melanoma: Unraveling a complex relationship. Oncogene, vol. 36, no. 42, pp. 5771-5792.
[31] Ross, A. L., Sanchez, M. I., and Grichnik, J. M. (2011). Molecular nevogenesis. Dermatology Research and Practice, 2011:463184. DOI: 10.1155/2011/463184.
[32] Al Hawsawi, K., Al Zahrani, B., Bamani, S., et al. (2016). Acquired melanocytic nevus:
An unusual case presentation. The Open Dermatology Journal, vol. 1, no. 1, pp. 6-8.