Download fulltext HTML
Sidabutar, E., Halim, B., Ganis Siregar, M. F., Lutan, D., Adenin, I., & Kaban, Y. (2016). Vitamin D Levels in Women with Polycystic Ovary Syndrome. KnE Medicine, 1(1), 125-132. https://doi.org/10.18502/kme.v1i1.547

https://doi.org/10.18502/kme.v1i1.547

statistics

  • 2188 Abstract Views
  • 274 PDF Views
  • 0 HTML Views

authors

  • Elida Sidabutar
    No author data available.
  • Binarwan Halim
    No author data available.
  • Muhammad Fidel Ganis Siregar
    No author data available.
  • Delfi Lutan
    No author data available.
  • Ichwanul Adenin
    No author data available.
  • Yostoto Kaban
    No author data available.

Published Date

  • Oct 4, 2016

Vitamin D Levels in Women with Polycystic Ovary Syndrome

KnE Medicine / The 6th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2016) / Pages 125-132

Abstract

INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome.

OBJECTIVE: To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome.

METHODS: This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed.

RESULTS: Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR> 0.85.

CONCLUSION: This study showed a significant lower level of vitamin D in PCOS patient.

References
[1] B. N. Kalro, T. L. Loucks, and S. L. Berga, Neuromodulation in polycystic ovary syndrome, Infertility and Reproductive Medicine Clinics of North America, 14, no. 4, 529–555, (2003).


[2] L. Speroff and MA. Fritz, Chronic Anovulation and The Polycystic Ovary Syndrome, in Clinical Gynecologic, Endocrinology and Infertility, 495–533, 2011, 8th ed.


[3] E. Wehr, S. Pilz, N. Schweighofer, A. Giuliani, D. Kopera, T. R. Pieber, and B. Obermayer-Pietsch, Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome, European Journal of Endocrinology, 161, no. 4, 575–582, (2009).


[4] E. Wehr, O. Trummer, A. Giuliani, H.-J. Gruber, T. R. Pieber, and B. Obermayer-Pietsch, Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome, European Journal of Endocrinology, 164, no. 5, 741–749, (2011).


[5] M. F. Holick, Medical progress: Vitamin D deficiency, New England Journal of Medicine, 357, no. 3, 266–281, (2007).


[6] L. Wamberg, T. Christiansen, S. K. Paulsen, S. Fisker, P. Rask, L. Rejnmark, B. Richelsen, and S. B. Pedersen, Expression of vitamin D-metabolizing enzymes in human adipose tissue - The effect of obesity and diet-induced weight loss, International Journal of Obesity, 37, no. 5, 651–657, (2013).


[7] S. M. Kabadi, B. K. Lee, and L. Liu, Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: Results from the NHANES 2001-2006, Diabetes Care, 35, no. 10, 2048–2054, (2012).


[8] P. Anagnostis, S. Karras, and D. G. Goulis, Vitamin D in human reproduction: A narrative review, International Journal of Clinical Practice, 67, no. 3, 225–235, (2013).


[9] M. Grundmann and F. Versen-Hoynck, Vitamin D-roles in womens reproductive health? Reprod Bio and Endocrinol, (2011).


[10] R. L. Thomson, S. Spedding, and J. D. Buckley, Vitamin D in the aetiology and management of polycystic ovary syndrome, Clinical Endocrinology, 77, no. 3, 343– 350, (2012).


[11] D. Bikle, J. Adams, and S. Christakos, Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition, 141–149, (2009).


[12] J. Wortsman, L. Y. Matsuoka, T. C. Chen, Z. Lu, and M. F. Holick, Decreased bioavailability of vitamin D in obesity, American Journal of Clinical Nutrition, 72, no. 3, 690–693, (2000).


[13] A. Bellia, C. Garcovich, M. D’Adamo, M. Lombardo, M. Tesauro, G. Donadel, P. Gentileschi, D. Lauro, M. Federici, R. Lauro, and P. Sbraccia, Serum 25- hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects, Internal and Emergency Medicine, 8, no. 1, 33–40, (2013).


[14] E. Lerchbaum and B. Obermayer-Pietsch, Mechanisms in endocrinology - Vitamin D and fertility: A systematic review, European Journal of Endocrinology, 166, no. 5, 765–778, (2012).


[15] L. Speroff and MA. Fritz, Obesity, in Clinical Gynecologic, Endocrinology and Infertility, 8th ed, 2011.


[16] R. Faraji, SH. Sharami, Z. Zahiri, et al., Evaluation of Relation between Anthropometric Indices and Vitamin D Concentrations in Women with Polycystic Ovarian Syndrome, Journal of Family and Reproductive Health, 8, no. 3, 123–129, (2014).


[17] SA. Yilmaz, SO. Altinkaya, A. Kebabcilar, et al., The relationship between polycystic ovary syndrome and vitamin D levels, J Turk Soc Obstet Gynecol, 1, 18–24, (2015).