Comparative Study Between Mock Embryo Transfer Prior To The Treatment Cycle and Real Embryo Transfer In In Vitro Fertilization
Abstract
Introduction
A trial or mock embryo transfer (ET) may influence pregnancy rates and it performed prior to ET allows the clinician to assess the uterine cavity and the utero-cervical angle. The aim of this study is to compare the consistency of the type of ET in mock ET with real ET.
Material & Methods
A retrospective comparative analysis of patients who underwent in vitro fertilization or ICSI cycle from January 2014 to December 2014 in Halim Fertility Center was done. The type of transfer was divided into two groups: ‘easy’ or ‘difficult’. An easy ET was defined as a transfer that occurred without the use of manipulation or other instrumentation and difficult ET was considered when additional instrumentation was required.
Results
From the study, 103 patients who underwent Mock-ET, we found 58 patients (56.3%) with easy ET and 45 patients (43.7%) with difficult ET, which with hard catheter ET in 17 patients (16.5%), with osfander assistance in 20 patients (19.4%) and with stylet in 8 patients (7,8%). 58 patients with Easy Mock ET group were entirely easy real ET (100%) and 45 patients with difficult Mock ET group also entirely were difficult real ET (100%). The Statistical analysis shows no significant difference between the mock ET and real ET groups (p>0,05). In easy real ET, clinical pregnancy rates were 32.8% and in difficult real ET, clinical pregnancy rates were 26.7% with no significant difference between the groups (p>0,05).
Conclusion:
Mock ET prior to the treatment cycle is consistent with real ET.
References
[1] H. N. Sallam, Embryo transfer: Factors involved in optimizing the success, Current Opinion in Obstetrics and Gynecology, 17, no. 3, 289–298, (2005).
[2] R. G. Edwards, Clinical approaches to increasing uterine receptivity during human implantation, Human Reproduction, 10, no. 2, 60–66, (1995).
[3] R. S. Derks, C. Farquhar, B. W. J. Mol, K. Buckingham, and M. J. Heineman, Techniques for preparation prior to embryo transfer, Cochrane Database of Systematic Reviews, no. 2, Article ID CD007682, (2009).
[4] N. Moossavifar, N. Khadem, and A. Torabizadeh, The correlation between mock embryo transfers prior to the start of IVF cycle with real embryo transfer, Iranian Journal of Reproductive Medicine, 4, no. 1, 19–22, (2006).
[5] L. Mains and B. J. Van Voorhis, Optimizing the technique of embryo transfer, Fertility and Sterility, 94, no. 3, 785–790, (2010).
[6] N. Singh, P. Gupta, S. Mittal, and N. Malhotra, Correlation of technical difficulty during embryo transfer with rate of clinical pregnancy, Journal of Human Reproductive Sciences, 5, no. 3, 258–261, (2012).
[7] F. Ghaffari, K. Kiani, A. Bahmanabadi, and M. Akhoond, Comparison of easy and difficult embryo transfer outcomes in in vitro fertilization cycles, International Journal of Fertility and Sterility, 6, no. 4, 232–237, (2013).
[8] R. Mansour, Minimizing embryo expulsion after embryo transfer: A randomized controlled study, Human Reproduction, 20, no. 1, 170–174, (2005).
[9] M. B. Henne and A. A. Milki, Uterine position at real embryo transfer compared with mock embryo transfer, Human Reproduction, 19, no. 3, 570–572, (2004).
[10] K. Sharif, M. Afnan, and W. Lenton, Mock embryo transfer with a full bladder immediately before the real transfer for in-vitro fertilization treatment: The Birmingham experience of 113 cases, Human Reproduction, 10, no. 7, 1715–1718, (1995).
[11] W. B. Schoolcraft, E. S. Surrey, and D. K. Gardner, Embryo transfer: Techniques and variables affecting success, Fertility and Sterility, 76, no. 5, 863–870, (2001).
[12] R. Mansour, M. Aboulghar, and G. Serour, Dummy embryo transfer: A technique that minimizes the problems of embryo transfer and improves the pregnancy rate in human in vitro fertilization, Fertility and Sterility, 54, no. 4, 678–681, (1990).
[13] R. T. Mansour, M. A. Aboulghar, G. I. Serour, and Y. M. Amin, Dummy embryo transfer using methylene blue dye, Human Reproduction, 9, no. 7, 1257–1259, (1994).
[14] R. T. Mansour and M. A. Aboulghar, Optimizing the embryo transfer technique, Human Reproduction, 17, no. 5, 1149–1153, (2002).
[15] F. Aletebi, A new safe embryo transfer technique and its impact on ICSI outcome, Middle East Fertility Society Journal, 15, no. 3, 153–158, (2010).
[16] A. Torre, J. B. Scheffer, L. M. Schönauer, N. Frydman, and R. Fanchin, Mock embryo transfer does not affect uterine contractility, Fertility and Sterility, 93, no. 4, 1343– 1346, (2010).
[17] K. O. Katariya, G. W. Bates, R. D. Robinson, N. J. Arthur, and A. M. Propst, Does the timing of mock embryo transfer affect in vitro fertilization implantation and pregnancy rates?, Fertility and Sterility, 88, no. 5, 1462–1464, (2007).