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Halim, B., Putri Lubis, H., & Novia, D. (2016). Outcome of Intra Uterine Insemination for HIV Serodiscordant Couple. KnE Medicine, 1(1), 49-54. https://doi.org/10.18502/kme.v1i1.536

https://doi.org/10.18502/kme.v1i1.536

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authors

  • Binarwan Halim
    No author data available.
  • Hilma Putri Lubis
    No author data available.
  • Diana Novia
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Published Date

  • Oct 4, 2016

Outcome of Intra Uterine Insemination for HIV Serodiscordant Couple

KnE Medicine / The 6th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2016) / Pages 49-54

Abstract

Introduction

HIV serodiscordant couple who wish to have offspring but fear of disease contagious prohibittedthem from concieved naturally. Intrauterine insemination without having direct sexual contact is one of the method to achieve this wish. This study was aimed to evaluate the outcome of intrauterine insemination in HIV serodiscordant couple.

Material and methods

Retrospective analytic study was done. HIV serodiscordant couple who have been treated with intrauterine insemination from January 2010 until June 2014 in Halim Fertility Centre Medan was included in this study.

Results

There were 27 cycles of intrauterine insemination from HIV serodiscordant couple. The clinical pregnancy rate were 33.3%. None of the babies or mother after deliveries have HIV positive.

Conclusion

Intrauterine insemination in HIV serodiscordant couple appears to be effective and safe method to achieve pregnancy. 

References
[1] M. Zafer, H. Horvath, O. Mmeje, SVD. Poel, AE. Semprini, G. Rutherford, et al., Effectiveness of semen washing to prevent human immune deficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis, Fertility and Sterility, 105, no. 3, 645–655, (2016).


[2] L. Bujan, M. Sergerie, N. Kiffer, N. Moinard, G. Seguela, B. Mercadier, P. Rhone, C. Pasquier, and M. Daudin, Good efficiency of intrauterine insemination programme for serodiscordant couples with HIV-1 infected male partner: A retrospective comparative study, European Journal of Obstetrics Gynecology and Reproductive
Biology, 135, no. 1, 76–82, (2007).


[3] L. Bujan, C. Pasquier, E. Labeyrie, P. Lanusse-Crousse, M. Morucci, and M. Daudin, Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child, Fertility and Sterility, 82, no. 4, 857–862, (2004).


[4] A. Schuffner, A. P. Lisboa, V. B. da Rosa, and M. M. Gomes da Silva, Use of assisted reproductive technology to separate sperm from human immunodeficiency virus infected men resulting in pregnancy among serodiscordant couples, Brazilian Journal of Infectious Diseases, 15, no. 4, 397–398, (2011).


[5] R. L. Vitorino, B. G. Grinsztejn, C. A. F. De Andrade, Y. H. M. Hökerberg, C. T. V. De Souza, R. K. Friedman, and S. R. L. Passos, Systematic review of the effectiveness and safety of assisted reproduction techniques in couples serodiscordant for human immunodeficiency virus where the man is positive, Fertility and Sterility, 95, no. 5,
1684–1690, (2011).


[6] J. L. Chen, K. A. Phillips, D. E. Kanouse, R. L. Collins, and A. Miu, Fertility Desires and Intentions of HIV-Positive Men and Women, Perspectives on Sexual and Reproductive Health, 33, no. 4, 144–165, (2001).


[7] Y. Manigart, S. Rozenberg, P. Barlow, M. Gerard, E. Bertrand, and A. Delvigne, ART outcome in HIV-infected patients, Human Reproduction, 21, no. 11, 2935–2940, (2006).


[8] K. Kashima, K. Takakuwa, M. Suzuki, M. Makino, S. Kaneko, S. Kato, H. Hanabusa, and K. Tanaka, Studies of assisted reproduction techniques (ART) for HIV-1-discordant couples using washed sperm and the nested PCR method: A comparison of the pregnancy rates in HIV-1-discordant couples and control couples, Japanese Journal
of Infectious Diseases, 62, no. 3, 173–176, (2009).


[9] A. E. Semprini, P. Levi-Setti, M. Bozzo, M. Ravizza, A. Taglioretti, P. Sulpizio, E. Albani, M. Oneta, and G. Pardi, Insemination of HIV-negative women with processed semen of HIV-positive partners, The Lancet, 340, no. 8831, 1317–1319, (1992).


[10] V. Savasi, E. Ferrazzi, C. Lanzani, M. Oneta, B. Parrilla, and T. Persico, Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples, Human Reproduction, 22, no. 3, 772–777, (2007).


[11] A. C. Eke and C. Oragwu, Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in sero-discordant couples., Cochrane database of systematic reviews (Online), 1, p. CD008498, (2011).


[12] A. Barnes, D. Riche, L. Mena, T. Sison, L. Barry, R. Reddy, J. Shwayder, and J. P. Parry, Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus: A systematic review and meta-analysis, Fertility and Sterility, 102, no. 2, 424–434, (2014).