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Stepanov, S. V., Dubov, L. Y., Akmalova, Y. A., Byakov, V. M., Shtotsky, Y. V., & Bokov, A. V. (2018). Carcinogenicity Screening of Chemicals Using Positron Annihilation Spectroscopy. KnE Energy, 3(2), 476–485. https://doi.org/10.18502/ken.v3i2.1854

https://doi.org/10.18502/ken.v3i2.1854

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authors

  • S V Stepanov
    No author data available.
  • L Yu Dubov
    No author data available.
  • Yu A Akmalova
    No author data available.
  • V M Byakov
    No author data available.
  • Yu V Shtotsky
    No author data available.
  • A V Bokov
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Published Date

  • Apr 17, 2018

Carcinogenicity Screening of Chemicals Using Positron Annihilation Spectroscopy

KnE Energy / The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine" / Pages 476–485

Abstract

Chemical carcinogens are the main cause of cancer. Many thousands of new chemicals are synthesized annually in the world, unknown part of them is carcinogens. There are several methods, which are currently used for testing carcinogenicity. The fastest arephysicochemical methods. We suggest the method of fast carcinogen screening using the positron annihilation spectroscopy (PAS). It is based on the fact that the presence of carcinogens, being strong electrophiles, significantly decreases positronium (Ps) formation probability. This quantity can be measured by means of conventional PAS techniques: positron annihilation lifetime spectroscopy (PALS), angular correlation of annihilation radiation (ACAR) or Doppler broadening of annihilation radiation (DBAR). It is also possible to evaluate anti-carcinogenic properties of chemicals using the anti-inhibition effect of Ps formation.


Keywords: carcinogen, electrophilicity, positron annihilation spectroscopy, positronium

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